SULT1A4 [The Human Chemical-Genetic Interaction Map Project]

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======= SULT1A4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SULT1A4
  * **<color #00a2e8>Official Name</color>**: sulfotransferase family 1A member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=445329|445329]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0DMN0|P0DMN0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SULT1A4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SULT1A4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615819|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sulfotransfer 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aryl sulfotransferase activity|
|3-phosphoadenosine 5-phosphosulfate metabolic process|
|purine ribonucleoside bisphosphate metabolic process|
|catecholamine metabolic process|
|catechol-containing compound metabolic process|
|phenol-containing compound metabolic process|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|steroid metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|nucleobase-containing small molecule metabolic process|
|organophosphate metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.571|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.467|
|[[:human genes:a:aatf|AATF]]|0.46|
|[[:human genes:t:twistnb|TWISTNB]]|0.453|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.448|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.444|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.444|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.444|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.443|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.443|
|[[:human genes:t:tceb3c|TCEB3C]]|0.441|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.44|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.438|
|[[:human genes:p:polr2d|POLR2D]]|0.437|
|[[:human genes:d:ddtl|DDTL]]|0.435|
|[[:human genes:s:slc6a17|SLC6A17]]|0.435|
|[[:human genes:c:chd4|CHD4]]|0.434|
|[[:human genes:p:pan2|PAN2]]|0.431|
|[[:human genes:p:psmd3|PSMD3]]|0.43|
|[[:human genes:p:psmd11|PSMD11]]|0.429|
|[[:human genes:r:rps2|RPS2]]|0.429|
|[[:human genes:p:psmb4|PSMB4]]|0.428|
|[[:human genes:s:slc38a7|SLC38A7]]|0.426|
|[[:human genes:o:orc1|ORC1]]|0.425|
|[[:human genes:p:psmb2|PSMB2]]|0.425|
|[[:human genes:c:copg1|COPG1]]|0.424|
|[[:human genes:p:psmd2|PSMD2]]|0.418|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.417|
|[[:human genes:e:exosc5|EXOSC5]]|0.416|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.414|
|[[:human genes:u:upf1|UPF1]]|0.414|
|[[:human genes:p:polr2j3|POLR2J3]]|0.413|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.412|
|[[:human genes:v:vasn|VASN]]|0.412|
|[[:human genes:p:pwp2|PWP2]]|0.411|
|[[:human genes:f:fcn2|FCN2]]|0.41|
|[[:human genes:p:psmc2|PSMC2]]|0.409|
|[[:human genes:v:vps28|VPS28]]|0.409|
|[[:human genes:b:bysl|BYSL]]|0.406|
|[[:human genes:p:psma6|PSMA6]]|0.406|
|[[:human genes:p:pola1|POLA1]]|0.405|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.405|
|[[:human genes:r:rps19|RPS19]]|0.403|
|[[:human genes:p:prim1|PRIM1]]|0.402|
|[[:human genes:s:syt9|SYT9]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2722
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SULT1A4 Expression in NALM6 Cells: 1.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>