SUMO2 [The Human Chemical-Genetic Interaction Map Project]

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======= SUMO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUMO2
  * **<color #00a2e8>Official Name</color>**: small ubiquitin like modifier 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6613|6613]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61956|P61956]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUMO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUMO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603042|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26524494, ECO:0000269|PubMed:9556629}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rad60-SLD|
|ubiquitin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein tag|
|transcription corepressor binding|
|ubiquitin-like protein ligase binding|
|protein sumoylation|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of ubiquitin-dependent protein catabolic process|
|PML body|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of proteasomal protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of cellular protein catabolic process|
|ubiquitin protein ligase binding|
|peptidyl-lysine modification|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|regulation of proteolysis|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|RNA binding|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.91|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.31|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.31|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-2.29|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-2.08|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.04|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-2.01|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.99|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.99|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.99|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.95|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.94|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.91|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.87|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.82|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.81|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.81|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.8|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.76|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.74|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.71|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.7|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.7|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.78|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.82|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.85|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.89|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.05|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.2|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.23|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.23|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|4.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gtf3c6|GTF3C6]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 32/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|3/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4363
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUMO2 Expression in NALM6 Cells: 7.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>