SUMO2

Entrez Summary: N/A
UniProt Summary: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26524494, ECO:0000269|PubMed:9556629}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ribavirin 10 to 15μM on day4 R04 exp160	-2.91
5-Azacytidine 2μM R07 exp330	-2.31
EPZ-5676 30μM R05 exp233	-2.31
PT-1 25μM R07 exp392	-2.29
L-BMAA 500 to 750μM on day4 R04 exp185	-2.08
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-2.04
Celastrol 0.12μM R05 exp225	-2.01
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.99
Temozolomide 200μM R04 exp189	-1.99
Wiskostatin 3μM R07 exp422	-1.99
Rapamycin 1μM R00 exp29	-1.95
UNC2400 2μM R03 exp156	-1.94
Quercetin 20μM R08 exp517	-1.91
GSK343 3μM R03 exp124	-1.87
Dimethyloxaloylglycine 11μM R07 exp314	-1.82
FK-506 5μM R07 exp358	-1.81
Hippuristanol 0.12μM R08 exp488	-1.81
Torin1 0.08μM R02 exp82	-1.8
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.76
Thimerosal 0.85μM R08 exp529	-1.74
TGF-beta1 44ng/ml R08 exp528	-1.71
Chloroquine 32μM R08 exp470	-1.7
Epigallocatechin gallate 20μM R05 exp230	-1.7
CB-5083 0.4μM R08 exp468	1.78
Salinomycin 3.5μM R08 exp521	1.82
Hinokiflavone 12μM R08 exp487	1.85
SNS-032 15μM R08 exp443	1.89
JQ1 0.8μM R08 exp435	2.05
Talazoparib 0.006μM R06 exp299	2.2
Actinomycin-D 0.01μM R00 exp4	2.23
UM131593 0.2μM R03 exp106	2.23
ML-792 0.2μM R08 exp505	4.11

Global Fraction of Cell Lines Where Essential: 32/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	0/26
breast	3/33
central nervous system	4/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	2/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	3/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	1/5

Expression Distribution

Rad60-SLD
ubiquitin

protein tag
transcription corepressor binding
ubiquitin-like protein ligase binding
protein sumoylation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of ubiquitin-dependent protein catabolic process
PML body
positive regulation of proteasomal protein catabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
regulation of cellular protein catabolic process
ubiquitin protein ligase binding
peptidyl-lysine modification
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
positive regulation of catabolic process
regulation of proteolysis
protein modification by small protein conjugation
regulation of cellular catabolic process
peptidyl-amino acid modification
protein modification by small protein conjugation or removal
regulation of catabolic process
RNA binding
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process