SURF6 [The Human Chemical-Genetic Interaction Map Project]

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======= SURF6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SURF6
  * **<color #00a2e8>Official Name</color>**: surfeit 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6838|6838]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75683|O75683]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SURF6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SURF6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/185642|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SURF6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|granular component|
|cytosolic large ribosomal subunit|
|ribosomal small subunit biogenesis|
|ribosomal large subunit biogenesis|
|ribosome biogenesis|
|ribonucleoprotein complex biogenesis|
|nucleolus|
|RNA binding|
|DNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.11|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.85|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.79|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.78|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.88|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.98|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.25|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 51/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|2/26|
|breast|2/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|0/20|
|lung|6/75|
|lymphocyte|2/16|
|ovary|3/26|
|pancreas|2/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 946
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SURF6 Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>