SURF6

Entrez Summary: N/A
UniProt Summary: Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 51/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	2/26
breast	2/33
central nervous system	5/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	2/21
liver	0/20
lung	6/75
lymphocyte	2/16
ovary	3/26
pancreas	2/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	1/29
uterus	0/5

Expression Distribution

granular component
cytosolic large ribosomal subunit
ribosomal small subunit biogenesis
ribosomal large subunit biogenesis
ribosome biogenesis
ribonucleoprotein complex biogenesis
nucleolus
RNA binding
DNA binding