SYAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= SYAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYAP1
  * **<color #00a2e8>Official Name</color>**: synapse associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=94056|94056]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96A49|Q96A49]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). {ECO:0000269|PubMed:23300339}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BSD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TORC2 signaling|
|cellular response to insulin-like growth factor stimulus|
|positive regulation of protein homodimerization activity|
|cellular response to platelet-derived growth factor stimulus|
|response to platelet-derived growth factor|
|regulation of protein homodimerization activity|
|TOR signaling|
|cellular response to epidermal growth factor stimulus|
|response to epidermal growth factor|
|positive regulation of fat cell differentiation|
|extrinsic component of cytoplasmic side of plasma membrane|
|presynaptic membrane|
|positive regulation of protein binding|
|regulation of fat cell differentiation|
|growth cone|
|perikaryon|
|cellular response to insulin stimulus|
|positive regulation of binding|
|postsynaptic membrane|
|regulation of protein binding|
|response to insulin|
|cellular response to peptide hormone stimulus|
|axon|
|cellular response to peptide|
|positive regulation of protein serine/threonine kinase activity|
|regulation of binding|
|response to peptide hormone|
|dendrite|
|response to peptide|
|cellular response to growth factor stimulus|
|regulation of protein serine/threonine kinase activity|
|response to growth factor|
|positive regulation of protein kinase activity|
|cell junction|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|perinuclear region of cytoplasm|
|regulation of protein kinase activity|
|regulation of kinase activity|
|response to hormone|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|Golgi apparatus|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18107
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYAP1 Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>