SYAP1

Entrez Summary: N/A
UniProt Summary: Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). {ECO:0000269|PubMed:23300339}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

TORC2 signaling
cellular response to insulin-like growth factor stimulus
positive regulation of protein homodimerization activity
cellular response to platelet-derived growth factor stimulus
response to platelet-derived growth factor
regulation of protein homodimerization activity
TOR signaling
cellular response to epidermal growth factor stimulus
response to epidermal growth factor
positive regulation of fat cell differentiation
extrinsic component of cytoplasmic side of plasma membrane
presynaptic membrane
positive regulation of protein binding
regulation of fat cell differentiation
growth cone
perikaryon
cellular response to insulin stimulus
positive regulation of binding
postsynaptic membrane
regulation of protein binding
response to insulin
cellular response to peptide hormone stimulus
axon
cellular response to peptide
positive regulation of protein serine/threonine kinase activity
regulation of binding
response to peptide hormone
dendrite
response to peptide
cellular response to growth factor stimulus
regulation of protein serine/threonine kinase activity
response to growth factor
positive regulation of protein kinase activity
cell junction
positive regulation of kinase activity
cellular response to organonitrogen compound
cellular response to hormone stimulus
positive regulation of transferase activity
cellular response to nitrogen compound
perinuclear region of cytoplasm