SYCP1

Entrez Summary: N/A
UniProt Summary: Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. {ECO:0000250|UniProtKB:Q62209}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lateral element assembly
transverse filament
meiotic DNA repair synthesis
chiasma assembly
central element
sperm chromatin condensation
male germ cell nucleus
synaptonemal complex assembly
spermatid nucleus differentiation
synaptonemal complex organization
synaptonemal complex
synapsis
DNA synthesis involved in DNA repair
reciprocal meiotic recombination
homologous recombination
chromosome, centromeric region
homologous chromosome segregation
chromosome organization involved in meiotic cell cycle
meiotic chromosome segregation
protein homotetramerization
double-stranded DNA binding
meiosis I
DNA biosynthetic process
meiosis I cell cycle process
nucleus organization
protein tetramerization
spermatid development
meiotic nuclear division
spermatid differentiation
meiotic cell cycle process
DNA packaging
nuclear chromosome segregation
DNA recombination
meiotic cell cycle
germ cell development
chromosome segregation
nuclear division
DNA conformation change
organelle fission
protein homooligomerization