SYNJ2

Entrez Summary: The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
UniProt Summary: Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
inositol phosphate dephosphorylation
phosphorylated carbohydrate dephosphorylation
inositol phosphate catabolic process
phosphatidylinositol dephosphorylation
polyol catabolic process
phospholipid dephosphorylation
alcohol catabolic process
inositol phosphate metabolic process
organic hydroxy compound catabolic process
PDZ domain binding
presynapse
phosphatidylinositol biosynthetic process
polyol metabolic process
organophosphate catabolic process
SH3 domain binding
phosphatidylinositol metabolic process
cellular carbohydrate metabolic process
lipid modification
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
membrane raft
phospholipid biosynthetic process
axon
glycerophospholipid metabolic process
dephosphorylation
alcohol metabolic process
cytoskeleton
phospholipid metabolic process
glycerolipid metabolic process
small molecule catabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
perinuclear region of cytoplasm
brain development
head development
membrane organization
organophosphate metabolic process