SYNJ2BP [The Human Chemical-Genetic Interaction Map Project]

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======= SYNJ2BP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYNJ2BP
  * **<color #00a2e8>Official Name</color>**: synaptojanin 2 binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55333|55333]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P57105|P57105]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYNJ2BP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYNJ2BP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609411|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. {ECO:0000250|UniProtKB:Q9D6K5}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular distribution of mitochondria|
|ionotropic glutamate receptor complex|
|mitochondrion distribution|
|integral component of mitochondrial outer membrane|
|postsynaptic density membrane|
|negative regulation of sprouting angiogenesis|
|ionotropic glutamate receptor binding|
|negative regulation of endothelial cell proliferation|
|receptor localization to synapse|
|receptor clustering|
|establishment or maintenance of epithelial cell apical/basal polarity|
|mitochondrion localization|
|negative regulation of endothelial cell migration|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|protein localization to synapse|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of epithelial cell migration|
|regulation of sprouting angiogenesis|
|neuromuscular junction|
|Rho protein signal transduction|
|localization within membrane|
|regulation of Notch signaling pathway|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|negative regulation of epithelial cell proliferation|
|regulation of endothelial cell proliferation|
|regulation of endothelial cell migration|
|negative regulation of MAPK cascade|
|protein C-terminus binding|
|establishment or maintenance of cell polarity|
|basolateral plasma membrane|
|regulation of endocytosis|
|regulation of epithelial cell migration|
|Ras protein signal transduction|
|protein-containing complex localization|
|negative regulation of cell migration|
|negative regulation of cell motility|
|regulation of angiogenesis|
|regulation of ERK1 and ERK2 cascade|
|negative regulation of cellular component movement|
|small GTPase mediated signal transduction|
|neuron projection|
|regulation of vasculature development|
|negative regulation of locomotion|
|regulation of epithelial cell proliferation|
|protein targeting|
|negative regulation of protein phosphorylation|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|mitochondrion organization|
|negative regulation of phosphorylation|
|synaptic signaling|
|protein localization to membrane|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|cell junction|
|regulation of vesicle-mediated transport|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|organelle localization|
|negative regulation of protein modification process|
|negative regulation of cell population proliferation|
|regulation of MAPK cascade|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|regulation of locomotion|
|intracellular protein transport|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|mitochondrion|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.93|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.446|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13867
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYNJ2BP Expression in NALM6 Cells: 4.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>