SYNJ2BP
Gene Information
- Official Symbol: SYNJ2BP
- Official Name: synaptojanin 2 binding protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 55333
- UniProt: P57105
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. {ECO:0000250|UniProtKB:Q9D6K5}.
Pfam Domains GO Terms
Pfam Domains
| PDZ |
GO Terms
| intracellular distribution of mitochondria |
| ionotropic glutamate receptor complex |
| mitochondrion distribution |
| integral component of mitochondrial outer membrane |
| postsynaptic density membrane |
| negative regulation of sprouting angiogenesis |
| ionotropic glutamate receptor binding |
| negative regulation of endothelial cell proliferation |
| receptor localization to synapse |
| receptor clustering |
| establishment or maintenance of epithelial cell apical/basal polarity |
| mitochondrion localization |
| negative regulation of endothelial cell migration |
| establishment or maintenance of apical/basal cell polarity |
| establishment or maintenance of bipolar cell polarity |
| protein localization to synapse |
| negative regulation of ERK1 and ERK2 cascade |
| negative regulation of epithelial cell migration |
| regulation of sprouting angiogenesis |
| neuromuscular junction |
| Rho protein signal transduction |
| localization within membrane |
| regulation of Notch signaling pathway |
| negative regulation of angiogenesis |
| negative regulation of blood vessel morphogenesis |
| negative regulation of vasculature development |
| negative regulation of epithelial cell proliferation |
| regulation of endothelial cell proliferation |
| regulation of endothelial cell migration |
| negative regulation of MAPK cascade |
| protein C-terminus binding |
| establishment or maintenance of cell polarity |
| basolateral plasma membrane |
| regulation of endocytosis |
| regulation of epithelial cell migration |
| Ras protein signal transduction |
| protein-containing complex localization |
| negative regulation of cell migration |
| negative regulation of cell motility |
| regulation of angiogenesis |
| regulation of ERK1 and ERK2 cascade |
| negative regulation of cellular component movement |
| small GTPase mediated signal transduction |
| neuron projection |
| regulation of vasculature development |
| negative regulation of locomotion |
| regulation of epithelial cell proliferation |
| protein targeting |
| negative regulation of protein phosphorylation |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| trans-synaptic signaling |
| mitochondrion organization |
| negative regulation of phosphorylation |
| synaptic signaling |
| protein localization to membrane |
| cell-cell adhesion |
| negative regulation of intracellular signal transduction |
| cell junction |
| regulation of vesicle-mediated transport |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| organelle localization |
| negative regulation of protein modification process |
| negative regulation of cell population proliferation |
| regulation of MAPK cascade |
| regulation of cell migration |
| regulation of cell motility |
| cell adhesion |
| biological adhesion |
| negative regulation of developmental process |
| regulation of locomotion |
| intracellular protein transport |
| regulation of cellular component movement |
| negative regulation of cellular protein metabolic process |
| regulation of anatomical structure morphogenesis |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| negative regulation of multicellular organismal process |
| mitochondrion |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| intracellular signal transduction |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Docetaxel 0.002μM R01 exp45 | -1.93 |
| Trimetrexate 0.03μM R08 exp535 | 1.84 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.446 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13867
- Expression level (log2 read counts): 4.65
Expression Distribution
SYNJ2BP Expression in NALM6 Cells: 4.65
