SYPL2

Entrez Summary: N/A
UniProt Summary: Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CCCP 0.1μM R00 exp10	-1.82
SNS-032 15μM R08 exp443	-1.73
Lead acetate 2000μM R08 exp498 no dilution day6	-1.72

T-tubule organization
syntaxin-1 binding
substantia nigra development
neural nucleus development
synaptic vesicle membrane
midbrain development
plasma membrane organization
muscle cell development
muscle cell differentiation
endomembrane system organization
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
muscle structure development
divalent inorganic cation homeostasis
heart development
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
brain development
cellular chemical homeostasis
head development
ion homeostasis
membrane organization
circulatory system development
cellular homeostasis
central nervous system development
chemical homeostasis
homeostatic process
cell development