SYT11
Gene Information
- Official Symbol: SYT11
- Official Name: synaptotagmin 11
- Aliases and Previous Symbols: N/A
- Entrez ID: 23208
- UniProt: Q9BT88
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| C2 |
GO Terms
| regulation of phagosome maturation |
| negative regulation of clathrin-coated pit assembly |
| regulation of protein localization to phagocytic vesicle |
| regulation of clathrin-coated pit assembly |
| positive regulation of protein localization to phagocytic vesicle |
| negative regulation of synaptic vesicle endocytosis |
| negative regulation of membrane invagination |
| calcium ion regulated lysosome exocytosis |
| negative regulation of synaptic vesicle recycling |
| negative regulation of clathrin-dependent endocytosis |
| negative regulation of tumor necrosis factor secretion |
| presynaptic active zone membrane |
| early phagosome |
| negative regulation of interleukin-6 secretion |
| negative regulation of neurotransmitter secretion |
| plasma membrane repair |
| inhibitory synapse |
| integral component of presynaptic active zone membrane |
| regulation of synaptic vesicle endocytosis |
| regulation of membrane invagination |
| regulation of clathrin-dependent endocytosis |
| regulation of defense response to bacterium |
| calcium ion-regulated exocytosis of neurotransmitter |
| negative regulation of phagocytosis |
| translation initiation factor binding |
| negative regulation of receptor-mediated endocytosis |
| negative regulation of neurotransmitter transport |
| regulation of synaptic vesicle recycling |
| exocytic vesicle |
| phagocytic cup |
| regulation of tumor necrosis factor secretion |
| excitatory synapse |
| integral component of synaptic vesicle membrane |
| beta-tubulin binding |
| clathrin binding |
| regulation of dopamine secretion |
| calcium-ion regulated exocytosis |
| negative regulation of interleukin-6 production |
| regulation of calcium ion-dependent exocytosis |
| negative regulation of endocytosis |
| terminal bouton |
| calcium-dependent phospholipid binding |
| phosphatidylserine binding |
| negative regulation of tumor necrosis factor production |
| phagocytic vesicle |
| negative regulation of synaptic transmission |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| regulation of catecholamine secretion |
| synaptic vesicle exocytosis |
| SNARE binding |
| negative regulation of cytokine secretion |
| cell body |
| Schaffer collateral - CA1 synapse |
| cellular response to calcium ion |
| plasma membrane organization |
| protein homotetramerization |
| regulation of amine transport |
| presynapse |
| regulation of phagocytosis |
| regulation of response to drug |
| regulation of receptor-mediated endocytosis |
| neurotransmitter secretion |
| signal release from synapse |
| regulation of neurotransmitter secretion |
| regulation of synaptic vesicle cycle |
| recycling endosome |
| synaptic vesicle cycle |
| synaptic vesicle |
| vesicle-mediated transport in synapse |
| negative regulation of protein secretion |
| negative regulation of peptide secretion |
| regulation of interleukin-6 production |
| regulation of neurotransmitter transport |
| regulation of tumor necrosis factor production |
| dendritic spine |
| protein tetramerization |
| response to calcium ion |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of regulated secretory pathway |
| signal release |
| neurotransmitter transport |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| cellular response to metal ion |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of endocytosis |
| cellular response to inorganic substance |
| regulation of exocytosis |
| negative regulation of secretion |
| lysosome |
| postsynaptic density |
| negative regulation of cytokine production |
| ubiquitin protein ligase binding |
| axon |
| neuron projection |
| positive regulation of cellular protein localization |
| protein homooligomerization |
| regulation of neurotransmitter levels |
| response to metal ion |
| endomembrane system organization |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| synaptic signaling |
| regulation of protein secretion |
| wound healing |
| negative regulation of transport |
| regulation of peptide secretion |
| protein complex oligomerization |
| regulation of response to biotic stimulus |
| response to inorganic substance |
| regulation of cellular protein localization |
| cell junction |
| regulation of vesicle-mediated transport |
| response to wounding |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| regulated exocytosis |
| negative regulation of cellular component organization |
| regulation of protein transport |
| calcium ion binding |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| regulation of multi-organism process |
| exocytosis |
| regulation of secretion |
| membrane organization |
| protein homodimerization activity |
| regulation of cellular localization |
| regulation of cellular component biogenesis |
| secretion by cell |
| regulation of protein localization |
| export from cell |
| regulation of response to external stimulus |
| cell-cell signaling |
| secretion |
| negative regulation of multicellular organismal process |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of response to stress |
| protein-containing complex assembly |
| establishment of localization in cell |
| protein-containing complex subunit organization |
| regulation of transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6362
- Expression level (log2 read counts): 2.7
Expression Distribution
SYT11 Expression in NALM6 Cells: 2.7
