SYT1 [The Human Chemical-Genetic Interaction Map Project]

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======= SYT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYT1
  * **<color #00a2e8>Official Name</color>**: synaptotagmin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6857|6857]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21579|P21579]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/185605|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of calcium ion-dependent exocytosis of neurotransmitter|
|fast, calcium ion-dependent exocytosis of neurotransmitter|
|synchronous neurotransmitter secretion|
|positive regulation of synaptic vesicle fusion to presynaptic active zone membrane|
|calcium-dependent activation of synaptic vesicle fusion|
|syntaxin-3 binding|
|clathrin-sculpted acetylcholine transport vesicle membrane|
|regulation of calcium ion-dependent exocytosis of neurotransmitter|
|clathrin-sculpted glutamate transport vesicle membrane|
|calcium ion sensor activity|
|clathrin-sculpted monoamine transport vesicle membrane|
|spontaneous neurotransmitter secretion|
|chromaffin granule membrane|
|spontaneous synaptic transmission|
|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|
|positive regulation of synaptic vesicle exocytosis|
|regulation of synaptic vesicle fusion to presynaptic active zone membrane|
|positive regulation of vesicle fusion|
|detection of calcium ion|
|dense core granule|
|presynaptic modulation of chemical synaptic transmission|
|1-phosphatidylinositol binding|
|calcium ion-regulated exocytosis of neurotransmitter|
|positive regulation of calcium ion-dependent exocytosis|
|neuron projection terminus|
|low-density lipoprotein particle receptor binding|
|positive regulation of neurotransmitter secretion|
|positive regulation of dendrite extension|
|regulation of dendrite extension|
|syntaxin-1 binding|
|exocytic vesicle|
|glutamate secretion|
|regulation of vesicle fusion|
|excitatory synapse|
|integral component of synaptic vesicle membrane|
|hippocampal mossy fiber to CA3 synapse|
|positive regulation of neurotransmitter transport|
|clathrin binding|
|regulation of dopamine secretion|
|calcium-ion regulated exocytosis|
|regulation of calcium ion-dependent exocytosis|
|synaptic vesicle endocytosis|
|presynaptic endocytosis|
|acidic amino acid transport|
|synaptic vesicle recycling|
|clathrin-coated vesicle membrane|
|positive regulation of regulated secretory pathway|
|syntaxin binding|
|calcium-dependent phospholipid binding|
|phosphatidylserine binding|
|calcium-dependent protein binding|
|regulation of catecholamine secretion|
|vesicle docking|
|synaptic vesicle exocytosis|
|SNARE binding|
|synaptic vesicle membrane|
|regulation of synaptic transmission, glutamatergic|
|presynaptic membrane|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of synaptic vesicle exocytosis|
|dicarboxylic acid transport|
|acid secretion|
|cellular response to calcium ion|
|positive regulation of exocytosis|
|regulation of amine transport|
|regulation of response to drug|
|neurotransmitter secretion|
|signal release from synapse|
|regulation of neurotransmitter secretion|
|protein heterooligomerization|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|amino acid transport|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|regulation of neurotransmitter transport|
|response to calcium ion|
|positive regulation of synaptic transmission|
|regulation of regulated secretory pathway|
|positive regulation of cell growth|
|signal release|
|organelle localization by membrane tethering|
|positive regulation of developmental growth|
|neurotransmitter transport|
|membrane docking|
|protein C-terminus binding|
|cellular response to metal ion|
|calmodulin binding|
|cellular response to inorganic substance|
|regulation of exocytosis|
|positive regulation of growth|
|positive regulation of neuron projection development|
|carboxylic acid transport|
|organic acid transport|
|axon|
|neuron projection|
|regulation of developmental growth|
|protein homooligomerization|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of neuron differentiation|
|response to metal ion|
|positive regulation of cell projection organization|
|positive regulation of secretion by cell|
|regulation of cell growth|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|positive regulation of neurogenesis|
|protein heterodimerization activity|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|protein complex oligomerization|
|detection of chemical stimulus|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|regulation of vesicle-mediated transport|
|endocytosis|
|organelle localization|
|anion transport|
|positive regulation of organelle organization|
|regulation of neuron differentiation|
|regulation of growth|
|import into cell|
|detection of stimulus|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulated exocytosis|
|regulation of cell projection organization|
|calcium ion binding|
|brain development|
|regulation of secretion by cell|
|head development|
|exocytosis|
|regulation of secretion|
|regulation of neurogenesis|
|membrane organization|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|central nervous system development|
|Golgi apparatus|
|positive regulation of transport|
|secretion by cell|
|export from cell|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell-cell signaling|
|secretion|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|ion transport|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13283
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYT1 Expression in NALM6 Cells: -1.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>