SYT1
Gene Information
- Official Symbol: SYT1
- Official Name: synaptotagmin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6857
- UniProt: P21579
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}.
Pfam Domains GO Terms
Pfam Domains
| C2 |
GO Terms
| positive regulation of calcium ion-dependent exocytosis of neurotransmitter |
| fast, calcium ion-dependent exocytosis of neurotransmitter |
| synchronous neurotransmitter secretion |
| positive regulation of synaptic vesicle fusion to presynaptic active zone membrane |
| calcium-dependent activation of synaptic vesicle fusion |
| syntaxin-3 binding |
| clathrin-sculpted acetylcholine transport vesicle membrane |
| regulation of calcium ion-dependent exocytosis of neurotransmitter |
| clathrin-sculpted glutamate transport vesicle membrane |
| calcium ion sensor activity |
| clathrin-sculpted monoamine transport vesicle membrane |
| spontaneous neurotransmitter secretion |
| chromaffin granule membrane |
| spontaneous synaptic transmission |
| clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane |
| positive regulation of synaptic vesicle exocytosis |
| regulation of synaptic vesicle fusion to presynaptic active zone membrane |
| positive regulation of vesicle fusion |
| detection of calcium ion |
| dense core granule |
| presynaptic modulation of chemical synaptic transmission |
| 1-phosphatidylinositol binding |
| calcium ion-regulated exocytosis of neurotransmitter |
| positive regulation of calcium ion-dependent exocytosis |
| neuron projection terminus |
| low-density lipoprotein particle receptor binding |
| positive regulation of neurotransmitter secretion |
| positive regulation of dendrite extension |
| regulation of dendrite extension |
| syntaxin-1 binding |
| exocytic vesicle |
| glutamate secretion |
| regulation of vesicle fusion |
| excitatory synapse |
| integral component of synaptic vesicle membrane |
| hippocampal mossy fiber to CA3 synapse |
| positive regulation of neurotransmitter transport |
| clathrin binding |
| regulation of dopamine secretion |
| calcium-ion regulated exocytosis |
| regulation of calcium ion-dependent exocytosis |
| synaptic vesicle endocytosis |
| presynaptic endocytosis |
| acidic amino acid transport |
| synaptic vesicle recycling |
| clathrin-coated vesicle membrane |
| positive regulation of regulated secretory pathway |
| syntaxin binding |
| calcium-dependent phospholipid binding |
| phosphatidylserine binding |
| calcium-dependent protein binding |
| regulation of catecholamine secretion |
| vesicle docking |
| synaptic vesicle exocytosis |
| SNARE binding |
| synaptic vesicle membrane |
| regulation of synaptic transmission, glutamatergic |
| presynaptic membrane |
| phosphatidylinositol-4,5-bisphosphate binding |
| regulation of synaptic vesicle exocytosis |
| dicarboxylic acid transport |
| acid secretion |
| cellular response to calcium ion |
| positive regulation of exocytosis |
| regulation of amine transport |
| regulation of response to drug |
| neurotransmitter secretion |
| signal release from synapse |
| regulation of neurotransmitter secretion |
| protein heterooligomerization |
| regulation of synaptic vesicle cycle |
| synaptic vesicle cycle |
| amino acid transport |
| synaptic vesicle |
| vesicle-mediated transport in synapse |
| regulation of neurotransmitter transport |
| response to calcium ion |
| positive regulation of synaptic transmission |
| regulation of regulated secretory pathway |
| positive regulation of cell growth |
| signal release |
| organelle localization by membrane tethering |
| positive regulation of developmental growth |
| neurotransmitter transport |
| membrane docking |
| protein C-terminus binding |
| cellular response to metal ion |
| calmodulin binding |
| cellular response to inorganic substance |
| regulation of exocytosis |
| positive regulation of growth |
| positive regulation of neuron projection development |
| carboxylic acid transport |
| organic acid transport |
| axon |
| neuron projection |
| regulation of developmental growth |
| protein homooligomerization |
| glutamatergic synapse |
| regulation of neurotransmitter levels |
| positive regulation of neuron differentiation |
| response to metal ion |
| positive regulation of cell projection organization |
| positive regulation of secretion by cell |
| regulation of cell growth |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| positive regulation of secretion |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| organic anion transport |
| synaptic signaling |
| positive regulation of neurogenesis |
| protein heterodimerization activity |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| protein complex oligomerization |
| detection of chemical stimulus |
| response to inorganic substance |
| positive regulation of nervous system development |
| positive regulation of cell development |
| cell junction |
| regulation of vesicle-mediated transport |
| endocytosis |
| organelle localization |
| anion transport |
| positive regulation of organelle organization |
| regulation of neuron differentiation |
| regulation of growth |
| import into cell |
| detection of stimulus |
| regulation of plasma membrane bounded cell projection organization |
| regulation of ion transport |
| regulated exocytosis |
| regulation of cell projection organization |
| calcium ion binding |
| brain development |
| regulation of secretion by cell |
| head development |
| exocytosis |
| regulation of secretion |
| regulation of neurogenesis |
| membrane organization |
| regulation of cellular localization |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| central nervous system development |
| Golgi apparatus |
| positive regulation of transport |
| secretion by cell |
| export from cell |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| cell-cell signaling |
| secretion |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| positive regulation of developmental process |
| ion transport |
| generation of neurons |
| protein-containing complex assembly |
| neurogenesis |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| MS023 7μM R03 exp135 | 1.75 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13283
- Expression level (log2 read counts): -1.26
Expression Distribution
SYT1 Expression in NALM6 Cells: -1.26
