SYT2

Entrez Summary: This gene encodes a synaptic vesicle membrane protein. The encoded protein is thought to function as a calcium sensor in vesicular trafficking and exocytosis. Mutations in this gene are associated with myasthenic syndrome, presynaptic, congenital, with or without motor neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
UniProt Summary: Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:P46097, ECO:0000269|PubMed:23999003}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

inositol 1,3,4,5 tetrakisphosphate binding
chromaffin granule membrane
dense core granule
calcium ion-regulated exocytosis of neurotransmitter
positive regulation of dendrite extension
regulation of dendrite extension
exocytic vesicle
clathrin binding
regulation of dopamine secretion
calcium-ion regulated exocytosis
regulation of calcium ion-dependent exocytosis
presynaptic endocytosis
synaptic vesicle endocytosis
synaptic vesicle recycling
clathrin-coated vesicle membrane
syntaxin binding
calcium-dependent phospholipid binding
phosphatidylserine binding
regulation of catecholamine secretion
synaptic vesicle exocytosis
SNARE binding
synaptic vesicle membrane
cellular response to calcium ion
regulation of amine transport
regulation of response to drug
neurotransmitter secretion
signal release from synapse
synaptic vesicle cycle
vesicle-mediated transport in synapse
response to calcium ion
regulation of regulated secretory pathway
positive regulation of cell growth
signal release
positive regulation of developmental growth
neurotransmitter transport
cellular response to metal ion
cellular response to inorganic substance
regulation of exocytosis
positive regulation of growth
positive regulation of neuron projection development