SYT6

Entrez Summary: The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011].
UniProt Summary: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)- regulation of exocytosis in acrosomal reaction in sperm (By similarity). {ECO:0000250|UniProtKB:Q9R0N8}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

neuronal dense core vesicle exocytosis
presynaptic dense core vesicle exocytosis
integral component of synaptic membrane
acrosomal vesicle exocytosis
dense core granule exocytosis
perinuclear endoplasmic reticulum
calcium ion-regulated exocytosis of neurotransmitter
acrosome reaction
exocytic vesicle
clathrin binding
regulation of dopamine secretion
calcium-ion regulated exocytosis
regulation of calcium ion-dependent exocytosis
syntaxin binding
calcium-dependent phospholipid binding
phosphatidylserine binding
calcium-dependent protein binding
regulation of catecholamine secretion
synaptic vesicle exocytosis
extrinsic component of membrane
SNARE binding
synaptic vesicle membrane
cellular response to calcium ion
regulation of amine transport
regulation of response to drug
neurotransmitter secretion
signal release from synapse
synaptic vesicle cycle
vesicle-mediated transport in synapse
single fertilization
response to calcium ion
regulation of regulated secretory pathway
signal release
fertilization
neurotransmitter transport
cellular response to metal ion
cellular response to inorganic substance
regulation of exocytosis
glutamatergic synapse
regulation of neurotransmitter levels