TAB2

Gene Information

Official Symbol: TAB2
Official Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 23118
UniProt: Q9NYJ8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
UniProt Summary: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:20493459}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11510
Expression level (log2 read counts): 5.67

Expression Distribution

K63-linked polyubiquitin modification-dependent protein binding
nucleotide-binding oligomerization domain containing signaling pathway
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
cytoplasmic pattern recognition receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
JNK cascade
negative regulation of autophagy
interleukin-1-mediated signaling pathway
toll-like receptor signaling pathway
stress-activated MAPK cascade
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
pattern recognition receptor signaling pathway
stress-activated protein kinase signaling cascade
positive regulation of NF-kappaB transcription factor activity
activation of MAPK activity
intracellular receptor signaling pathway
Fc-epsilon receptor signaling pathway
cellular response to interleukin-1
T cell receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to interleukin-1
endosome membrane
innate immune response-activating signal transduction
regulation of I-kappaB kinase/NF-kappaB signaling
Fc receptor signaling pathway
negative regulation of cellular catabolic process
activation of innate immune response
positive regulation of MAP kinase activity
positive regulation of DNA-binding transcription factor activity
antigen receptor-mediated signaling pathway
negative regulation of catabolic process
response to lipopolysaccharide
response to molecule of bacterial origin
activation of protein kinase activity
regulation of autophagy
positive regulation of protein serine/threonine kinase activity
positive regulation of innate immune response
regulation of MAP kinase activity