TACR1

Entrez Summary: This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008].
UniProt Summary: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

substance P receptor activity
tachykinin receptor activity
tachykinin receptor signaling pathway
sperm head
regulation of uterine smooth muscle contraction
positive regulation of flagellated sperm motility
positive regulation of cilium-dependent cell motility
regulation of flagellated sperm motility
sperm midpiece
regulation of cilium-dependent cell motility
response to pain
sperm flagellum
regulation of smooth muscle contraction
multicellular organismal response to stress
positive regulation of reproductive process
phospholipase C-activating G protein-coupled receptor signaling pathway
detection of abiotic stimulus
regulation of reproductive process
regulation of muscle contraction
regulation of muscle system process
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
inflammatory response
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
cellular metal ion homeostasis
regulation of system process
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
detection of stimulus
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis