TACSTD2 [The Human Chemical-Genetic Interaction Map Project]

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======= TACSTD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TACSTD2
  * **<color #00a2e8>Official Name</color>**: tumor associated calcium signal transducer 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4070|4070]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09758|P09758]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TACSTD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TACSTD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137290|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a growth factor receptor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thyroglobulin 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of branching involved in ureteric bud morphogenesis|
|negative regulation of mesonephros development|
|negative regulation of ruffle assembly|
|negative regulation of substrate adhesion-dependent cell spreading|
|negative regulation of morphogenesis of an epithelium|
|negative regulation of kidney development|
|cadherin binding involved in cell-cell adhesion|
|negative regulation of stress fiber assembly|
|positive regulation of stem cell differentiation|
|regulation of branching involved in ureteric bud morphogenesis|
|negative regulation of actin filament bundle assembly|
|regulation of mesonephros development|
|negative regulation of plasma membrane bounded cell projection assembly|
|regulation of ruffle assembly|
|basal plasma membrane|
|negative regulation of animal organ morphogenesis|
|regulation of substrate adhesion-dependent cell spreading|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of kidney development|
|regulation of morphogenesis of a branching structure|
|lateral plasma membrane|
|negative regulation of cell-substrate adhesion|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|negative regulation of epithelial cell migration|
|nephron morphogenesis|
|renal tubule morphogenesis|
|nephron tubule development|
|regulation of stress fiber assembly|
|renal tubule development|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|regulation of actomyosin structure organization|
|mesonephros development|
|regulation of actin filament bundle assembly|
|nephron epithelium development|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of stem cell differentiation|
|bicellular tight junction|
|nephron development|
|kidney epithelium development|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|regulation of morphogenesis of an epithelium|
|negative regulation of cell projection organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of cell-substrate adhesion|
|regulation of epithelial cell migration|
|visual perception|
|sensory perception of light stimulus|
|regulation of animal organ morphogenesis|
|negative regulation of cell migration|
|regulation of actin filament organization|
|kidney development|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|renal system development|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|urogenital system development|
|negative regulation of locomotion|
|negative regulation of cell development|
|regulation of epithelial cell proliferation|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of actin filament-based process|
|morphogenesis of an epithelium|
|regulation of cell morphogenesis|
|cell-cell adhesion|
|regulation of cytoskeleton organization|
|tissue morphogenesis|
|tube morphogenesis|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|tube development|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|sensory perception|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|negative regulation of multicellular organismal process|
|regulation of organelle organization|
|positive regulation of developmental process|
|nervous system process|
|extracellular space|
|regulation of cell population proliferation|
|tissue development|
|regulation of cell differentiation|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13064
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TACSTD2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>