TACSTD2

Gene Information

Official Symbol: TACSTD2
Official Name: tumor associated calcium signal transducer 2
Aliases and Previous Symbols: N/A
Entrez ID: 4070
UniProt: P09758
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009].
UniProt Summary: May function as a growth factor receptor.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13064
Expression level (log2 read counts): -7.68

Expression Distribution

negative regulation of branching involved in ureteric bud morphogenesis
negative regulation of mesonephros development
negative regulation of ruffle assembly
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of morphogenesis of an epithelium
negative regulation of kidney development
cadherin binding involved in cell-cell adhesion
negative regulation of stress fiber assembly
positive regulation of stem cell differentiation
regulation of branching involved in ureteric bud morphogenesis
negative regulation of actin filament bundle assembly
regulation of mesonephros development
negative regulation of plasma membrane bounded cell projection assembly
regulation of ruffle assembly
basal plasma membrane
negative regulation of animal organ morphogenesis
regulation of substrate adhesion-dependent cell spreading
ureteric bud morphogenesis
mesonephric tubule morphogenesis
regulation of kidney development
regulation of morphogenesis of a branching structure
lateral plasma membrane
negative regulation of cell-substrate adhesion
nephron tubule morphogenesis
nephron epithelium morphogenesis
negative regulation of epithelial cell migration
nephron morphogenesis
renal tubule morphogenesis
nephron tubule development
regulation of stress fiber assembly
renal tubule development
kidney morphogenesis
ureteric bud development
mesonephric tubule development
mesonephric epithelium development
regulation of actomyosin structure organization
mesonephros development
regulation of actin filament bundle assembly
nephron epithelium development
negative regulation of cell morphogenesis involved in differentiation