TAF11 [The Human Chemical-Genetic Interaction Map Project]

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======= TAF11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAF11
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein associated factor 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6882|6882]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15544|Q15544]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAF11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAF11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600772|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TAFII28|
|CBFD NFYB HMF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II preinitiation complex assembly|
|vitamin D receptor binding|
|positive regulation by host of viral transcription|
|transcription preinitiation complex assembly|
|thyroid hormone receptor binding|
|transcription factor TFIID complex|
|positive regulation of viral transcription|
|regulation of viral transcription|
|snRNA transcription by RNA polymerase II|
|modification by host of symbiont morphology or physiology|
|snRNA transcription|
|interaction with symbiont|
|ncRNA transcription|
|protein N-terminus binding|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|modification of morphology or physiology of other organism|
|transcription initiation from RNA polymerase II promoter|
|regulation of signal transduction by p53 class mediator|
|protein-DNA complex assembly|
|regulation of viral process|
|DNA-templated transcription, initiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|protein-DNA complex subunit organization|
|transcription coactivator activity|
|transcription factor binding|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|positive regulation of multi-organism process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|Golgi apparatus|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.93|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.77|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.74|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.83|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.88|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.21|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.26|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.62|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.438|
|[[:human genes:d:dohh|DOHH]]|0.423|
|[[:human genes:t:taf13|TAF13]]|0.408|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4036
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAF11 Expression in NALM6 Cells: 5.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>