TAF11

Gene Information

Official Symbol: TAF11
Official Name: TATA-box binding protein associated factor 11
Aliases and Previous Symbols: N/A
Entrez ID: 6882
UniProt: Q15544
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R02 exp89	-1.93
Nicotinamide 2000μM R01 exp50	-1.77
SNS-032 15μM R08 exp443	1.74
ONC212 0.15μM R08 exp513	1.83
5-Azacytidine 2μM R07 exp330	1.88
Fluvastatin 2.2μM R06 exp282	2.21
Staurosporine 0.02μM R08 exp524	2.26
Benzoate 20000μM R08 exp456	2.62
Trimetrexate 0.03μM R08 exp535	3.04

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4036
Expression level (log2 read counts): 5.56

Expression Distribution

Gene	Correlation
THG1L	0.438
DOHH	0.423
TAF13	0.408
GTF3C4	0.405

TAFII28
CBFD NFYB HMF

RNA polymerase II preinitiation complex assembly
vitamin D receptor binding
positive regulation by host of viral transcription
transcription preinitiation complex assembly
thyroid hormone receptor binding
transcription factor TFIID complex
positive regulation of viral transcription
regulation of viral transcription
snRNA transcription by RNA polymerase II
modification by host of symbiont morphology or physiology
snRNA transcription
interaction with symbiont
ncRNA transcription
protein N-terminus binding
positive regulation of viral process
modification of morphology or physiology of other organism involved in symbiotic interaction
modification of morphology or physiology of other organism
transcription initiation from RNA polymerase II promoter
regulation of signal transduction by p53 class mediator
protein-DNA complex assembly
regulation of viral process
DNA-templated transcription, initiation
regulation of symbiosis, encompassing mutualism through parasitism
protein-DNA complex subunit organization
transcription coactivator activity
transcription factor binding
transcription by RNA polymerase II
protein heterodimerization activity
positive regulation of multi-organism process
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of multi-organism process
symbiotic process
interspecies interaction between organisms
cellular protein-containing complex assembly
Golgi apparatus
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process