TAF1A [The Human Chemical-Genetic Interaction Map Project]

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======= TAF1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAF1A
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein associated factor, RNA polymerase I subunit A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9015|9015]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15573|Q15573]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAF1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAF1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604903|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre- initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:7801123}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase I transcription factor complex|
|transcription elongation from RNA polymerase I promoter|
|termination of RNA polymerase I transcription|
|transcription initiation from RNA polymerase I promoter|
|transcription by RNA polymerase I|
|positive regulation of gene expression, epigenetic|
|DNA-templated transcription, termination|
|DNA-templated transcription, elongation|
|microtubule cytoskeleton|
|DNA-templated transcription, initiation|
|regulation of gene expression, epigenetic|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-2.01|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-2|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.93|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.91|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.89|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.84|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.83|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.77|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.72|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.505|
|[[:human genes:t:thg1l|THG1L]]|0.484|
|[[:human genes:g:gemin8|GEMIN8]]|0.484|
|[[:human genes:d:ddx20|DDX20]]|0.48|
|[[:human genes:s:srp14|SRP14]]|0.472|
|[[:human genes:p:pmm2|PMM2]]|0.467|
|[[:human genes:a:alg1|ALG1]]|0.45|
|[[:human genes:g:gemin7|GEMIN7]]|0.446|
|[[:human genes:g:gemin6|GEMIN6]]|0.443|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.441|
|[[:human genes:r:rpp21|RPP21]]|0.433|
|[[:human genes:e:exoc4|EXOC4]]|0.432|
|[[:human genes:e:eif3f|EIF3F]]|0.431|
|[[:human genes:r:rptor|RPTOR]]|0.431|
|[[:human genes:l:lsm10|LSM10]]|0.427|
|[[:human genes:u:uhrf1|UHRF1]]|0.425|
|[[:human genes:t:ten1|TEN1]]|0.424|
|[[:human genes:a:adsl|ADSL]]|0.419|
|[[:human genes:u:utp23|UTP23]]|0.419|
|[[:human genes:d:dhrsx|DHRSX]]|0.417|
|[[:human genes:c:cep57|CEP57]]|0.417|
|[[:human genes:t:txnl4b|TXNL4B]]|0.417|
|[[:human genes:d:dpagt1|DPAGT1]]|0.417|
|[[:human genes:u:uxt|UXT]]|0.417|
|[[:human genes:n:nsmce1|NSMCE1]]|0.415|
|[[:human genes:s:snapc5|SNAPC5]]|0.414|
|[[:human genes:r:rtcb|RTCB]]|0.413|
|[[:human genes:r:rnmt|RNMT]]|0.413|
|[[:human genes:z:zrsr2|ZRSR2]]|0.41|
|[[:human genes:r:rpia|RPIA]]|0.409|
|[[:human genes:v:vezt|VEZT]]|0.408|
|[[:human genes:p:ppp4c|PPP4C]]|0.408|
|[[:human genes:p:ppcs|PPCS]]|0.407|
|[[:human genes:p:ppa2|PPA2]]|0.404|
|[[:human genes:t:triap1|TRIAP1]]|0.404|
|[[:human genes:g:gmppb|GMPPB]]|0.403|
|[[:human genes:a:atxn10|ATXN10]]|0.402|
|[[:human genes:d:ddx39a|DDX39A]]|0.402|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.402|
|[[:human genes:p:pggt1b|PGGT1B]]|0.402|
|[[:human genes:p:ppp6c|PPP6C]]|0.401|
|[[:human genes:g:gemin4|GEMIN4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3150
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAF1A Expression in NALM6 Cells: 4.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>