TAF1A

Official Symbol: TAF1A
Official Name: TATA-box binding protein associated factor, RNA polymerase I subunit A
Aliases and Previous Symbols: N/A
Entrez ID: 9015
UniProt: Q15573
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre- initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:7801123}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 11μM R07 exp314	-2.01
CCCP 0.1μM R00 exp10	-2
Nocodazole 0.02μM R00 exp23	-1.93
Epigallocatechin gallate 20μM R05 exp230	-1.91
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.89
Quinacrine 2.5μM R03 exp146	-1.84
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.83
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.77
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.72
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.71

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RNA polymerase I transcription factor complex
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
positive regulation of gene expression, epigenetic
DNA-templated transcription, termination
DNA-templated transcription, elongation
microtubule cytoskeleton
DNA-templated transcription, initiation
regulation of gene expression, epigenetic
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of gene expression
gene expression