TAF1D

Official Symbol: TAF1D
Official Name: TATA-box binding protein associated factor, RNA polymerase I subunit D
Aliases and Previous Symbols: N/A
Entrez ID: 79101
UniProt: Q9H5J8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 41/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	2/25
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	1/15
kidney	3/21
liver	2/20
lung	4/75
lymphocyte	2/14
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	2/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	3/22
urinary tract	1/29
uterus	0/5

Expression Distribution

RNA polymerase transcription factor SL1 complex
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
positive regulation of gene expression, epigenetic
DNA-templated transcription, termination
DNA-templated transcription, elongation
microtubule organizing center
DNA-templated transcription, initiation
regulation of gene expression, epigenetic
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of gene expression
gene expression