TAF5 [The Human Chemical-Genetic Interaction Map Project]

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======= TAF5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAF5
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein associated factor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6877|6877]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15542|Q15542]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAF5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAF5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601787|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFIID 90kDa|
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II general transcription initiation factor activity|
|transcription factor TFTC complex|
|transcription factor TFIID complex|
|histone acetyltransferase activity|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|protein dimerization activity|
|transcription initiation from RNA polymerase II promoter|
|regulation of signal transduction by p53 class mediator|
|protein acylation|
|DNA-templated transcription, initiation|
|actin cytoskeleton|
|transcription regulatory region DNA binding|
|nuclear chromatin|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|chromatin organization|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|nucleolus|
|peptidyl-amino acid modification|
|chromosome organization|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.87|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.82|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.72|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.71|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.83|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 538/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|21/28|
|bone|20/25|
|breast|23/33|
|central nervous system|46/56|
|cervix|3/4|
|colorectal|11/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|10/15|
|kidney|17/21|
|liver|11/20|
|lung|52/75|
|lymphocyte|13/14|
|ovary|22/26|
|pancreas|16/24|
|peripheral nervous system|8/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|23/24|
|soft tissue|5/7|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|20/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3018
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAF5 Expression in NALM6 Cells: 5.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>