TAF5

Entrez Summary: N/A
UniProt Summary: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 538/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	20/28
blood	21/28
bone	20/25
breast	23/33
central nervous system	46/56
cervix	3/4
colorectal	11/17
esophagus	8/13
fibroblast	0/1
gastric	10/15
kidney	17/21
liver	11/20
lung	52/75
lymphocyte	13/14
ovary	22/26
pancreas	16/24
peripheral nervous system	8/16
plasma cell	13/15
prostate	0/1
skin	23/24
soft tissue	5/7
thyroid	2/2
upper aerodigestive	14/22
urinary tract	20/29
uterus	2/5

Expression Distribution

TFIID 90kDa
WD40

RNA polymerase II general transcription initiation factor activity
transcription factor TFTC complex
transcription factor TFIID complex
histone acetyltransferase activity
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
protein dimerization activity
transcription initiation from RNA polymerase II promoter
regulation of signal transduction by p53 class mediator
protein acylation
DNA-templated transcription, initiation
actin cytoskeleton
transcription regulatory region DNA binding
nuclear chromatin
peptidyl-lysine modification
histone modification
covalent chromatin modification
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
chromatin organization
viral process
symbiotic process
interspecies interaction between organisms
nucleolus
peptidyl-amino acid modification
chromosome organization
identical protein binding
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process