TAF8

Entrez Summary: N/A
UniProt Summary: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). {ECO:0000250, ECO:0000269|PubMed:14580349}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 384/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	20/28
blood	7/28
bone	15/25
breast	13/33
central nervous system	28/56
cervix	2/4
colorectal	9/17
esophagus	4/13
fibroblast	0/1
gastric	10/15
kidney	15/21
liver	8/20
lung	37/75
lymphocyte	10/14
ovary	13/26
pancreas	10/24
peripheral nervous system	10/16
plasma cell	9/15
prostate	0/1
skin	19/24
soft tissue	4/7
thyroid	2/2
upper aerodigestive	9/22
urinary tract	15/29
uterus	3/5

Expression Distribution

TAF8 C
Bromo TP

inner cell mass cell proliferation
blastocyst growth
maintenance of protein location in nucleus
transcription factor TFIID complex
maintenance of protein localization in organelle
snRNA transcription by RNA polymerase II
snRNA transcription
maintenance of protein location in cell
ncRNA transcription
maintenance of location in cell
blastocyst development
maintenance of protein location
regulation of fat cell differentiation
protein localization to nucleus
maintenance of location
in utero embryonic development
developmental growth
growth
transcription by RNA polymerase II
protein heterodimerization activity
cell population proliferation
chordate embryonic development
transcription, DNA-templated
nucleic acid-templated transcription
embryo development ending in birth or egg hatching
RNA biosynthetic process
perinuclear region of cytoplasm
protein localization to organelle
embryo development
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
positive regulation of transcription, DNA-templated
cellular protein localization
cellular macromolecule localization
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process