TALDO1 [The Human Chemical-Genetic Interaction Map Project]

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======= TALDO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TALDO1
  * **<color #00a2e8>Official Name</color>**: transaldolase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6888|6888]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P37837|P37837]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TALDO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TALDO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602063|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Transaldolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity|
|xylulose biosynthetic process|
|xylulose metabolic process|
|pentose biosynthetic process|
|pentose-phosphate shunt, non-oxidative branch|
|glyceraldehyde-3-phosphate metabolic process|
|fructose 6-phosphate metabolic process|
|pentose-phosphate shunt|
|monosaccharide binding|
|NADPH regeneration|
|pentose metabolic process|
|glucose 6-phosphate metabolic process|
|NADP metabolic process|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|response to interleukin-12|
|monosaccharide biosynthetic process|
|cellular aldehyde metabolic process|
|carbohydrate biosynthetic process|
|monosaccharide metabolic process|
|generation of precursor metabolites and energy|
|carbohydrate metabolic process|
|small molecule biosynthetic process|
|cytokine-mediated signaling pathway|
|organophosphate metabolic process|
|oxidation-reduction process|
|cellular response to cytokine stimulus|
|carbohydrate derivative metabolic process|
|response to cytokine|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3573
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TALDO1 Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>