TALDO1

Entrez Summary: Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008].
UniProt Summary: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity
xylulose biosynthetic process
xylulose metabolic process
pentose biosynthetic process
pentose-phosphate shunt, non-oxidative branch
glyceraldehyde-3-phosphate metabolic process
fructose 6-phosphate metabolic process
pentose-phosphate shunt
monosaccharide binding
NADPH regeneration
pentose metabolic process
glucose 6-phosphate metabolic process
NADP metabolic process
interleukin-12-mediated signaling pathway
cellular response to interleukin-12
response to interleukin-12
monosaccharide biosynthetic process
cellular aldehyde metabolic process
carbohydrate biosynthetic process
monosaccharide metabolic process
generation of precursor metabolites and energy
carbohydrate metabolic process
small molecule biosynthetic process
cytokine-mediated signaling pathway
organophosphate metabolic process
oxidation-reduction process
cellular response to cytokine stimulus
carbohydrate derivative metabolic process
response to cytokine
small molecule metabolic process