TAPBP

Gene Information

Official Symbol: TAPBP
Official Name: TAP binding protein
Aliases and Previous Symbols: N/A
Entrez ID: 6892
UniProt: O15533
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8110
Expression level (log2 read counts): 7.99

Expression Distribution

TAP complex binding
peptide antigen stabilization
MHC class Ib protein complex assembly
peptide stabilization
ATPase-coupled peptide antigen transmembrane transporter activity
TAP2 binding
TAP1 binding
MHC protein complex assembly
vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
MHC class I peptide loading complex
regulation of protein complex stability
antigen processing and presentation of endogenous peptide antigen via MHC class I
antigen processing and presentation of endogenous peptide antigen
MHC class I protein binding
antigen processing and presentation of endogenous antigen
integral component of lumenal side of endoplasmic reticulum membrane
peptide antigen binding
endoplasmic reticulum-Golgi intermediate compartment membrane
vesicle fusion
phagocytic vesicle membrane
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
organelle membrane fusion
antigen processing and presentation of exogenous peptide antigen via MHC class I
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
organelle fusion
antigen processing and presentation of peptide antigen via MHC class I
membrane fusion
unfolded protein binding
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
antigen processing and presentation
vesicle organization
Golgi vesicle transport
peptide metabolic process
Golgi membrane
cellular amide metabolic process
cellular protein-containing complex assembly
membrane organization
endoplasmic reticulum membrane