TBCC [The Human Chemical-Genetic Interaction Map Project]

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======= TBCC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBCC
  * **<color #00a2e8>Official Name</color>**: tubulin folding cofactor C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6903|6903]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15814|Q15814]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBCC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBCC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602971|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Tubulin-folding protein; involved in the final step of the tubulin folding pathway. {ECO:0000269|PubMed:11847227}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TBCC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-chaperonin tubulin folding pathway|
|tubulin complex assembly|
|photoreceptor connecting cilium|
|tubulin binding|
|chaperone binding|
|protein folding|
|microtubule|
|GTPase activity|
|cytoskeleton|
|cell morphogenesis|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.34|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.27|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.19|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.97|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.95|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.94|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.81|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.81|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.77|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.72|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.76|
|[[:results:exp495|IWR1 50μM R08 exp495]]|2.02|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.31|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.41|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 566/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|18/28|
|blood|18/28|
|bone|18/26|
|breast|25/33|
|central nervous system|40/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|11/21|
|liver|16/20|
|lung|55/75|
|lymphocyte|14/16|
|ovary|20/26|
|pancreas|18/24|
|peripheral nervous system|12/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|24/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 192
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBCC Expression in NALM6 Cells: 4.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>