TBCC

Entrez Summary: N/A
UniProt Summary: Tubulin-folding protein; involved in the final step of the tubulin folding pathway. {ECO:0000269|PubMed:11847227}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SB743921 0.001μM R05 exp244	-2.34
Milciclib 2μM R08 exp502	-2.27
Doxorubicin 0.02μM R08 exp478	-2.19
Mitomycin-C 0.06μM R08 exp503	-1.97
Rapamycin 2μM R07 exp306	-1.95
Adefovir 20μM R07 exp332	-1.94
BI-6727 0.04μM R03 exp98	-1.81
CI-1040 9.5μM R08 exp472	-1.81
5-Azacytidine 2μM R07 exp330	-1.77
HMS-I1 10μM R06 exp256	-1.72
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.76
IWR1 50μM R08 exp495	2.02
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.31
Methotrexate 0.01μM R08 exp501	2.41
Vinblastine 0.002μM R01 exp60	2.63

Global Fraction of Cell Lines Where Essential: 566/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	18/28
blood	18/28
bone	18/26
breast	25/33
central nervous system	40/56
cervix	4/4
colorectal	14/17
esophagus	8/13
fibroblast	1/1
gastric	13/16
kidney	11/21
liver	16/20
lung	55/75
lymphocyte	14/16
ovary	20/26
pancreas	18/24
peripheral nervous system	12/16
plasma cell	15/15
prostate	1/1
skin	18/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	19/22
urinary tract	24/29
uterus	4/5

Expression Distribution

post-chaperonin tubulin folding pathway
tubulin complex assembly
photoreceptor connecting cilium
tubulin binding
chaperone binding
protein folding
microtubule
GTPase activity
cytoskeleton
cell morphogenesis
cellular component morphogenesis
cellular protein-containing complex assembly
protein-containing complex assembly
protein-containing complex subunit organization