TBL1X

Gene Information

Official Symbol: TBL1X
Official Name: transducin beta like 1 X-linked
Aliases and Previous Symbols: N/A
Entrez ID: 6907
UniProt: O60907
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008].
UniProt Summary: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. {ECO:0000269|PubMed:14980219}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/14
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18238
Expression level (log2 read counts): 6.9

Expression Distribution

Screen	Score
Isoniazid 100μM R08 exp494	1.71
iCRT14 30μM R08 exp492	1.81

LisH
WD40

histone deacetylase complex
histone deacetylation
protein deacetylation
transcriptional repressor complex
protein deacylation
macromolecule deacylation
mitotic spindle
beta-catenin binding
histone binding
positive regulation of canonical Wnt signaling pathway
sensory perception of sound
sensory perception of mechanical stimulus
positive regulation of Wnt signaling pathway
protein stabilization
protein C-terminus binding
transcription regulatory region DNA binding
transcription corepressor activity
protein domain specific binding
regulation of canonical Wnt signaling pathway
regulation of protein stability
proteasome-mediated ubiquitin-dependent protein catabolic process
transcription factor binding
proteasomal protein catabolic process
regulation of Wnt signaling pathway
histone modification
covalent chromatin modification
regulation of lipid metabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
chromatin organization
negative regulation of transcription by RNA polymerase II
cellular macromolecule catabolic process
sensory perception
macromolecule catabolic process
organonitrogen compound catabolic process
chromosome organization