TBL2

Entrez Summary: This gene encodes a member of the beta-transducin protein family. Most proteins of the beta-transducin family are involved in regulatory functions. This protein is possibly involved in some intracellular signaling pathway. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

translation initiation factor binding
phosphoprotein binding
cellular response to glucose starvation
endoplasmic reticulum unfolded protein response
integral component of endoplasmic reticulum membrane
cellular response to unfolded protein
cellular response to topologically incorrect protein
cellular response to starvation
response to unfolded protein
response to topologically incorrect protein
cellular response to hypoxia
response to starvation
cellular response to decreased oxygen levels
cellular response to oxygen levels
cellular response to nutrient levels
response to endoplasmic reticulum stress
cellular response to extracellular stimulus
cellular response to external stimulus
response to hypoxia
response to decreased oxygen levels
response to oxygen levels
protein kinase binding
response to nutrient levels
response to extracellular stimulus
endoplasmic reticulum
response to abiotic stimulus
RNA binding
cellular response to stress