TBPL1 [The Human Chemical-Genetic Interaction Map Project]

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======= TBPL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBPL1
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9519|9519]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62380|P62380]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBPL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBPL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605521|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box. {ECO:0000269|PubMed:10082669, ECO:0000269|PubMed:10220372, ECO:0000269|PubMed:15767669, ECO:0000269|PubMed:24958592}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase III regulatory region DNA binding|
|pyrimidine deoxyribonucleoside triphosphate biosynthetic process|
|dTTP biosynthetic process|
|dTTP metabolic process|
|deoxyribonucleoside triphosphate biosynthetic process|
|transcription factor TFIIIB complex|
|transcription factor TFIIA complex|
|pyrimidine deoxyribonucleoside triphosphate metabolic process|
|RNA polymerase III preinitiation complex assembly|
|pyrimidine deoxyribonucleotide biosynthetic process|
|2-deoxyribonucleotide biosynthetic process|
|deoxyribose phosphate biosynthetic process|
|transcription initiation from RNA polymerase III promoter|
|deoxyribonucleotide biosynthetic process|
|acrosome assembly|
|deoxyribonucleoside triphosphate metabolic process|
|pyrimidine nucleoside triphosphate biosynthetic process|
|pyrimidine deoxyribonucleotide metabolic process|
|spermatid nucleus differentiation|
|pyrimidine nucleoside triphosphate metabolic process|
|transcription preinitiation complex assembly|
|2-deoxyribonucleotide metabolic process|
|deoxyribose phosphate metabolic process|
|RNA polymerase II core promoter sequence-specific DNA binding|
|deoxyribonucleotide metabolic process|
|secretory granule organization|
|transcription factor TFIID complex|
|transcription by RNA polymerase III|
|pyrimidine nucleotide biosynthetic process|
|pyrimidine-containing compound biosynthetic process|
|pyrimidine nucleotide metabolic process|
|nucleoside triphosphate biosynthetic process|
|nucleoside triphosphate metabolic process|
|cellular component assembly involved in morphogenesis|
|pyrimidine-containing compound metabolic process|
|nucleus organization|
|spermatid development|
|spermatid differentiation|
|protein-DNA complex assembly|
|transcription factor complex|
|DNA-templated transcription, initiation|
|protein-DNA complex subunit organization|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|germ cell development|
|transcription coactivator activity|
|vesicle organization|
|transcription factor binding|
|cellular process involved in reproduction in multicellular organism|
|endomembrane system organization|
|nucleotide metabolic process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|nucleoside phosphate metabolic process|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|spermatogenesis|
|male gamete generation|
|carbohydrate derivative biosynthetic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|gamete generation|
|organelle assembly|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|multi-organism reproductive process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.78|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19039
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBPL1 Expression in NALM6 Cells: 4.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>