TBPL1

Gene Information

Official Symbol: TBPL1
Official Name: TATA-box binding protein like 1
Aliases and Previous Symbols: N/A
Entrez ID: 9519
UniProt: P62380
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011].
UniProt Summary: Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box. {ECO:0000269|PubMed:10082669, ECO:0000269|PubMed:10220372, ECO:0000269|PubMed:15767669, ECO:0000269|PubMed:24958592}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 19039
Expression level (log2 read counts): 4.49

Expression Distribution

Screen	Score
GSK343 3μM R03 exp124	-1.78
Cincreasin 100μM R08 exp473	1.74

RNA polymerase III regulatory region DNA binding
pyrimidine deoxyribonucleoside triphosphate biosynthetic process
dTTP biosynthetic process
dTTP metabolic process
deoxyribonucleoside triphosphate biosynthetic process
transcription factor TFIIIB complex
transcription factor TFIIA complex
pyrimidine deoxyribonucleoside triphosphate metabolic process
RNA polymerase III preinitiation complex assembly
pyrimidine deoxyribonucleotide biosynthetic process
2-deoxyribonucleotide biosynthetic process
deoxyribose phosphate biosynthetic process
transcription initiation from RNA polymerase III promoter
deoxyribonucleotide biosynthetic process
acrosome assembly
deoxyribonucleoside triphosphate metabolic process
pyrimidine nucleoside triphosphate biosynthetic process
pyrimidine deoxyribonucleotide metabolic process
spermatid nucleus differentiation
pyrimidine nucleoside triphosphate metabolic process
transcription preinitiation complex assembly
2-deoxyribonucleotide metabolic process
deoxyribose phosphate metabolic process
RNA polymerase II core promoter sequence-specific DNA binding
deoxyribonucleotide metabolic process
secretory granule organization
transcription factor TFIID complex
transcription by RNA polymerase III
pyrimidine nucleotide biosynthetic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
nucleoside triphosphate biosynthetic process
nucleoside triphosphate metabolic process
cellular component assembly involved in morphogenesis
pyrimidine-containing compound metabolic process
nucleus organization
spermatid development
spermatid differentiation
protein-DNA complex assembly
transcription factor complex