TBX19

Entrez Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008].
UniProt Summary: Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters. {ECO:0000269|PubMed:11290323}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

enhancer sequence-specific DNA binding
pituitary gland development
RNA polymerase II activating transcription factor binding
somitogenesis
mesoderm formation
mesoderm morphogenesis
diencephalon development
somite development
cell fate specification
segmentation
formation of primary germ layer
endocrine system development
mesoderm development
gastrulation
anterior/posterior pattern specification
nuclear chromatin
cell fate commitment
heart morphogenesis
RNA polymerase II regulatory region sequence-specific DNA binding
regionalization
forebrain development
gland development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
heart development
tissue morphogenesis
embryonic morphogenesis
chordate embryonic development
embryo development ending in birth or egg hatching
brain development
head development
negative regulation of transcription by RNA polymerase II
circulatory system development
anatomical structure formation involved in morphogenesis
animal organ morphogenesis
embryo development
central nervous system development
epithelium development
negative regulation of transcription, DNA-templated