TCAP [The Human Chemical-Genetic Interaction Map Project]

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======= TCAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TCAP
  * **<color #00a2e8>Official Name</color>**: titin-cap
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8557|8557]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15273|O15273]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TCAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TCAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604488|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Telethonin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|titin Z domain binding|
|sarcomerogenesis|
|detection of muscle stretch|
|FATZ binding|
|otic vesicle formation|
|otic vesicle morphogenesis|
|striated muscle myosin thick filament assembly|
|skeletal muscle myosin thick filament assembly|
|BMP binding|
|myosin filament organization|
|myosin filament assembly|
|cardiac muscle adaptation|
|skeletal muscle thin filament assembly|
|otic vesicle development|
|muscle hypertrophy in response to stress|
|titin binding|
|cardiac muscle hypertrophy in response to stress|
|adult heart development|
|skeletal myofibril assembly|
|cardiac muscle fiber development|
|response to muscle stretch|
|I band|
|cardiac myofibril assembly|
|striated muscle adaptation|
|cardiac muscle hypertrophy|
|skeletal muscle contraction|
|striated muscle hypertrophy|
|muscle hypertrophy|
|muscle adaptation|
|muscle filament sliding|
|actin-myosin filament sliding|
|musculoskeletal movement|
|multicellular organismal movement|
|detection of mechanical stimulus|
|sarcomere organization|
|structural constituent of muscle|
|muscle fiber development|
|cardiac muscle cell development|
|somitogenesis|
|cardiac cell development|
|myofibril assembly|
|cardiac muscle tissue morphogenesis|
|cardiac muscle contraction|
|protein binding, bridging|
|muscle tissue morphogenesis|
|somite development|
|muscle organ morphogenesis|
|heart contraction|
|cardiac muscle cell differentiation|
|actin-mediated cell contraction|
|segmentation|
|inner ear morphogenesis|
|heart process|
|cellular component assembly involved in morphogenesis|
|striated muscle contraction|
|actin filament-based movement|
|actomyosin structure organization|
|cardiocyte differentiation|
|ear morphogenesis|
|detection of external stimulus|
|detection of abiotic stimulus|
|ion channel binding|
|epithelial tube formation|
|Z disc|
|striated muscle cell development|
|tube formation|
|muscle cell development|
|cardiac muscle tissue development|
|inner ear development|
|striated muscle cell differentiation|
|response to mechanical stimulus|
|anterior/posterior pattern specification|
|ear development|
|actin filament organization|
|muscle cell differentiation|
|muscle contraction|
|heart morphogenesis|
|sensory organ morphogenesis|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|epithelial tube morphogenesis|
|regionalization|
|blood circulation|
|circulatory system process|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|heart development|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|detection of stimulus|
|organelle assembly|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|cytoskeleton organization|
|epithelium development|
|response to abiotic stimulus|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|cell development|
|tissue development|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp115|A-366 10μM R03 exp115]]|1.71|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12678
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TCAP Expression in NALM6 Cells: -0.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>