TCAP

Entrez Summary: Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008].
UniProt Summary: Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
A-366 10μM R03 exp115	1.71
QNZ 0.01μM R05 exp241	1.74

titin Z domain binding
sarcomerogenesis
detection of muscle stretch
FATZ binding
otic vesicle formation
otic vesicle morphogenesis
striated muscle myosin thick filament assembly
skeletal muscle myosin thick filament assembly
BMP binding
myosin filament organization
myosin filament assembly
cardiac muscle adaptation
skeletal muscle thin filament assembly
otic vesicle development
muscle hypertrophy in response to stress
titin binding
cardiac muscle hypertrophy in response to stress
adult heart development
skeletal myofibril assembly
cardiac muscle fiber development
response to muscle stretch
I band
cardiac myofibril assembly
striated muscle adaptation
cardiac muscle hypertrophy
skeletal muscle contraction
striated muscle hypertrophy
muscle hypertrophy
muscle adaptation
muscle filament sliding
actin-myosin filament sliding
musculoskeletal movement
multicellular organismal movement
detection of mechanical stimulus
sarcomere organization
structural constituent of muscle
muscle fiber development
cardiac muscle cell development
somitogenesis
cardiac cell development