TCF12 [The Human Chemical-Genetic Interaction Map Project]

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======= TCF12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TCF12
  * **<color #00a2e8>Official Name</color>**: transcription factor 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6938|6938]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99081|Q99081]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TCF12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TCF12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600480|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cAMP response element binding|
|enhancer binding|
|HMG box domain binding|
|bHLH transcription factor binding|
|E-box binding|
|SMAD binding|
|RNA polymerase II transcription factor complex|
|regulation of hematopoietic stem cell differentiation|
|regulation of hematopoietic progenitor cell differentiation|
|regulation of stem cell differentiation|
|transcription factor complex|
|transcription regulatory region DNA binding|
|nuclear chromatin|
|muscle organ development|
|transcription factor binding|
|positive regulation of neuron differentiation|
|nuclear speck|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|positive regulation of neurogenesis|
|muscle structure development|
|protein heterodimerization activity|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of neuron differentiation|
|DNA-binding transcription factor activity|
|intracellular membrane-bounded organelle|
|regulation of neurogenesis|
|protein homodimerization activity|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of developmental process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.92|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.54|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.3|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.29|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.22|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.18|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.15|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-2.12|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.06|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.05|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.01|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.98|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.89|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.83|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.82|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.75|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.71|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.7|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tcf3|TCF3]]|0.495|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17808
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TCF12 Expression in NALM6 Cells: 6.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>