TCF12

Entrez Summary: The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008].
UniProt Summary: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Milciclib 2μM R08 exp502	-2.92
LY2090314 0.003μM R08 exp499	-2.54
Actinomycin-D 0.001μM R00 exp3	-2.3
UM0129480 7μM R02 exp85	-2.29
Oligomycin-A 2μM R00 exp25	-2.22
Azithromycin 100μM R08 exp452	-2.18
CB-839 10μM R05 exp224	-2.15
UNC1999 2μM R03 exp155	-2.12
NN-Dimethylsphingosine 2.5μM R08 exp508	-2.06
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.05
LY2090314 0.003μM R08 exp500 no dilution day6	-2.01
GW501516 25μM R06 exp285	-1.98
Mdivi-1 15μM R05 exp217	-1.89
SGC0946 7μM R03 exp151	-1.83
Oligomycin-A 20μM R00 exp26	-1.82
GSK626616 14μM R08 exp485	-1.75
AICAR 240μM R03 exp116	-1.71
Bisphenol A 100μM R06 exp269	-1.7
Hypoxia 5%O2 R04 exp191	1.94

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cAMP response element binding
enhancer binding
HMG box domain binding
bHLH transcription factor binding
E-box binding
SMAD binding
RNA polymerase II transcription factor complex
regulation of hematopoietic stem cell differentiation
regulation of hematopoietic progenitor cell differentiation
regulation of stem cell differentiation
transcription factor complex
transcription regulatory region DNA binding
nuclear chromatin
muscle organ development
transcription factor binding
positive regulation of neuron differentiation
nuclear speck
DNA-binding transcription activator activity, RNA polymerase II-specific
regulation of hemopoiesis
positive regulation of neurogenesis
muscle structure development
protein heterodimerization activity
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
DNA-binding transcription factor activity
intracellular membrane-bounded organelle
regulation of neurogenesis
protein homodimerization activity
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
positive regulation of transcription by RNA polymerase II
positive regulation of developmental process
generation of neurons
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis
positive regulation of nucleic acid-templated transcription