TCF7L1

Entrez Summary: N/A
UniProt Summary: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CTNNB1 binding
HMG box

beta-catenin-TCF complex assembly
beta-catenin binding
canonical Wnt signaling pathway
transcription factor complex
transcription regulatory region DNA binding
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
chromatin binding
sequence-specific DNA binding
cell surface receptor signaling pathway involved in cell-cell signaling
DNA-binding transcription factor activity
chromatin organization
chromosome organization
cell-cell signaling
DNA binding
protein-containing complex assembly
DNA-binding transcription factor activity, RNA polymerase II-specific
protein-containing complex subunit organization