TCN1

Entrez Summary: N/A
UniProt Summary: Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cobalt ion transport
cobalamin transport
cobalamin binding
cobalamin metabolic process
vitamin transport
cofactor transport
tertiary granule lumen
tetrapyrrole metabolic process
specific granule lumen
water-soluble vitamin metabolic process
transition metal ion transport
vitamin metabolic process
drug transport
divalent inorganic cation transport
cofactor metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
drug metabolic process
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
metal ion transport
regulated exocytosis
leukocyte mediated immunity
exocytosis
cation transport
leukocyte activation
secretion by cell
response to drug
export from cell
cell activation
immune effector process
secretion
ion transport