TDO2

Entrez Summary: N/A
UniProt Summary: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. {ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:25066423, ECO:0000269|PubMed:27762317}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

response to nitroglycerin
tryptophan catabolic process to acetyl-CoA
tryptophan 2,3-dioxygenase activity
tryptophan catabolic process to kynurenine
indolalkylamine catabolic process
tryptophan catabolic process
indole-containing compound catabolic process
kynurenine metabolic process
tryptophan metabolic process
indolalkylamine metabolic process
amino acid binding
cellular biogenic amine catabolic process
amine catabolic process
indole-containing compound metabolic process
benzene-containing compound metabolic process
aromatic amino acid family catabolic process
acetyl-CoA metabolic process
oxygen binding
aromatic amino acid family metabolic process
cellular biogenic amine metabolic process
cellular amine metabolic process
amine metabolic process
cellular ketone metabolic process
protein homotetramerization
acyl-CoA metabolic process
thioester metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
ribonucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
heme binding
protein tetramerization
alpha-amino acid metabolic process
coenzyme metabolic process
carboxylic acid catabolic process
organic acid catabolic process
response to xenobiotic stimulus
cellular amino acid metabolic process
purine ribonucleotide metabolic process