TDRD12

Entrez Summary: N/A
UniProt Summary: Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. {ECO:0000250|UniProtKB:Q9CWU0}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CCT251545 20μM R07 exp326	1.7
Metformin 100 to 150μM on day4 R04 exp170	1.71

PET complex
piRNA metabolic process
DNA methylation involved in gamete generation
DNA methylation
DNA alkylation
male meiotic nuclear division
RNA helicase activity
DNA methylation or demethylation
gene silencing by RNA
DNA modification
gene silencing
meiotic nuclear division
meiotic cell cycle process
fertilization
nucleic acid binding
meiotic cell cycle
macromolecule methylation
nuclear division
organelle fission
methylation
cellular process involved in reproduction in multicellular organism
cellular component
ncRNA metabolic process
spermatogenesis
male gamete generation
gamete generation
DNA metabolic process
molecular function
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
cell cycle process
cell cycle
reproductive process
reproduction
ATP binding
RNA metabolic process
negative regulation of gene expression