TDRD5 [The Human Chemical-Genetic Interaction Map Project]

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======= TDRD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TDRD5
  * **<color #00a2e8>Official Name</color>**: tudor domain containing 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=163589|163589]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NAT2|Q8NAT2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TDRD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TDRD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617748|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OST LOTUS|
|TUDOR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oocyte anterior/posterior axis specification|
|pole plasm assembly|
|P granule organization|
|oocyte axis specification|
|maternal determination of anterior/posterior axis, embryo|
|oocyte construction|
|pi-body|
|cytoplasm organization|
|chromatoid body|
|anterior/posterior axis specification, embryo|
|tripartite regional subdivision|
|blastoderm segmentation|
|DNA methylation involved in gamete generation|
|embryonic axis specification|
|oocyte development|
|oocyte differentiation|
|DNA methylation|
|DNA alkylation|
|anterior/posterior axis specification|
|embryonic pattern specification|
|DNA methylation or demethylation|
|oogenesis|
|axis specification|
|DNA modification|
|segmentation|
|female gamete generation|
|spermatid development|
|spermatid differentiation|
|cell maturation|
|anterior/posterior pattern specification|
|developmental maturation|
|ribonucleoprotein complex subunit organization|
|macromolecule methylation|
|germ cell development|
|methylation|
|regionalization|
|cellular process involved in reproduction in multicellular organism|
|pattern specification process|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|DNA metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|embryo development|
|multi-organism reproductive process|
|reproductive process|
|reproduction|
|cell development|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.7|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12861
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TDRD5 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>