TDRD9

Entrez Summary: N/A
UniProt Summary: ATP-binding RNA helicase required during spermatogenesis (PubMed:28536242). Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4. {ECO:0000250|UniProtKB:Q14BI7, ECO:0000269|PubMed:28536242}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

piP-body
piRNA metabolic process
3-5 RNA helicase activity
DNA methylation involved in gamete generation
negative regulation of transposition
regulation of transposition
male meiosis I
DNA alkylation
DNA methylation
male meiotic nuclear division
DNA methylation or demethylation
gene silencing by RNA
DNA modification
meiosis I
meiosis I cell cycle process
meiotic nuclear division
gene silencing
meiotic cell cycle process
fertilization
meiotic cell cycle
ATPase activity
macromolecule methylation
nuclear division
methylation
organelle fission
cellular process involved in reproduction in multicellular organism
ncRNA metabolic process
spermatogenesis
male gamete generation
gamete generation
DNA metabolic process
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
cell cycle process
cell cycle
RNA binding
reproductive process
reproduction