TECRL

Entrez Summary: The protein encoded by this gene contains a ubiquitin-like domain in the N-terminal region, three transmembrane segments and a C-terminal 3-oxo-5-alpha steroid 4-dehydrogenase domain. The protein belongs to the steroid 5-alpha reductase family. Mutations in this gene result in ventricular tachycardia, catecholaminergic polymorphic, 3. [provided by RefSeq, Apr 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

oxidoreductase activity, acting on the CH-CH group of donors
very long-chain fatty acid biosynthetic process
very long-chain fatty acid metabolic process
oxidoreductase activity
fatty acid biosynthetic process
monocarboxylic acid biosynthetic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
endoplasmic reticulum
organic acid metabolic process
lipid metabolic process
small molecule metabolic process